5.38773
Nitric Oxide Production Inhibitor, 8-Gly Carb
Synonym(s):
2-Amino-N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)acetamide Trifluoroacetate, NO Inhibitor, 8-Gly Carb
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About This Item
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
assay
≥98% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
beige
solubility
DMSO: 25 mg/mL
storage temp.
2-8°C
General description
A cell-permeable carboline derived compound that acts as an inhibitor of both the constitutive (IC50 = 7 µM) and the inducible (IC50 = 7 µM and 20 µM for TNFalpha and LPS-induced) production of nitric oxide (·NO) in rat peritoneal macrophages in a manner independent of NF-κB activation. Only at higher concentrations (~ 100 µM), it inhibits NF-κB-mediated gene expression in differentiated THP1-XBlue cells. Shown to be about 40-fold more effective than NG-nitro-L-arginine in inhibiting ·NO production and 15-fold more effective in blocking LPS-induced ·NO production. Does not affect LPS- or TNFalpha-mediated cytokine production in THP1-XBlue cells and has no effect on ERK1/2 and p38 phosphorylation in TNFalpha stimulated THP1-XBlue cells.
Biochem/physiol Actions
Cell permeable: yes
Reversible: yes
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grodzki, A.C., et al. 2015. J. Pharm. Exp. Ther.352, 438.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 5387730001 | 04054839119675 |