Merck
CN
All Photos(1)

Documents

540215

Sigma-Aldrich

PTP CD45 Inhibitor

The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
PTP CD45 Inhibitor, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inh, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhi
Empirical Formula (Hill Notation):
C19H17NO3
CAS Number:
345630-40-2
Molecular Weight:
307.34

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

red-violet

solubility

DMSO: 5 mg/mL
ethanol: 5 mg/mL

shipped in

wet ice

storage temp.

2-8°C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI key

VZQDDSYKVYARDW-UHFFFAOYSA-N

General description

A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM using pNPP as the substrate, 3.8 µM for CD45 lck, >30 µM for PTP1B lck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC50 = 100 nM). Shown to be less cytotoxic (CC50 = 3.5 µM) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
CD45 using pNPP as a substrate
Product does not compete with ATP.
Reversible: yes
Target IC50: 200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Other Notes

Li, Y., et al. 2011. Blood117, 6702.
Urbanek, R.A., et al. 2001. J. Med. Chem.44, 1777.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Xiaorong Hu et al.
Aging, 13(2), 2768-2779 (2021-01-08)
Atherosclerosis is the main cause of cardiovascular disease. Systemic inflammation is one important characteristic in atherosclerosis. Pro-inflammatory macrophages can secrete inflammatory factors and promote the inflammation of atherosclerosis. It has a great value for the treatment of atherosclerosis by inhibiting
Peter Szodoray et al.
Cell reports, 36(6), 109525-109525 (2021-08-12)
Humoral immunity relies on the efficient differentiation of memory B cells (MBCs) into antibody-secreting cells (ASCs). T helper (Th) signals upregulate B cell receptor (BCR) signaling by potentiating Src family kinases through increasing CD45 phosphatase activity (CD45 PA). In this

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service