559307
Sangivamycin - CAS 18417-89-5 - Calbiochem
Synonym(s):
Sangivamycin - CAS 18417-89-5 - Calbiochem, 7-Deaza-7-carbamoyladenosine, NSC-65346
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About This Item
InChI
1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)
InChI key
OBZJZDHRXBKKTJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
0.1 M KOH: 5 mg/mL
shipped in
ambient
Quality Level
General description
This product has been discontinued.
A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
Biochem/physiol Actions
Other Notes
Osada, H., et al. 1989. J. Antibiot. 42, 402.
Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
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Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Regulatory Information
Certificates of Analysis (COA)
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