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Merck
CN

565610

SC-560

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM).

Synonym(s):

SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole

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About This Item

Empirical Formula (Hill Notation):
C18H12F3IN2O
CAS Number:
188817-13-2
Molecular Weight:
456.20
MDL number:
MFCD02179214
UNSPSC Code:
12352200

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3

InChI key

PQUGCKBLVKJMNT-UHFFFAOYSA-N

General description

A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM against COX-1

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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