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Merck
CN

565777

γ-Secretase Inhibitor XVI

The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester

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About This Item

Empirical Formula (Hill Notation):
C20H20F2N2O4
CAS Number:
208255-51-0
Molecular Weight:
390.38
UNSPSC Code:
12352200

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Product Name

γ-Secretase Inhibitor XVI, The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

InChI key

XAPDRNSTUYCSQC-SGTLLEGYSA-N

InChI

1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1

assay

≥97% (HPLC)

form

solid

potency

10 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 2 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC50 ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.

Other Notes

Walsh, D.M., et al. 2002. Nature 416, 535.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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