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Merck
CN

566327

Sigma-Aldrich

SIRT1/2 Inhibitor VII

The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):
C15H10N2O2S
CAS Number:
143034-06-4
Molecular Weight:
282.32
UNSPSC Code:
12352200

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Quality Level

100

Assay

≥95% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 3 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC50 = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD+-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Uciechowska, U., et al. 2008. ChemMedChem3, 1965.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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