567733
S1P1 Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem
The S1P1 Receptor Agonist, SEW2871, also referenced under CAS 256414-75-2, controls the biological activity of S1P1 Receptor. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
Synonym(s):
S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem
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About This Item
Empirical Formula (Hill Notation):
C20H10F6N2OS
CAS Number:
Molecular Weight:
440.36
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
Quality Level
storage temp.
2-8°C
General description
A cell-permeable oxadiazolothienyl compound that acts as a potent and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
A cell-permeable, potent, and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
Biochem/physiol Actions
Cell permeable: yes
EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively
Primary Target
S1P1 Receptor
S1P1 Receptor
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
Sanna, M.G., et al. 2004. J. Biol. Chem.279, 13839.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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Veronique E Miron et al.
Methods in molecular biology (Clifton, N.J.), 874, 141-154 (2012-04-25)
Measuring the effects of sphingosine-1-phosphate (S1P) receptor modulators on human primary neural cells is of particular interest given the recent application of these central nervous system-accessible agents to the treatment of neurodegenerative diseases, such as multiple sclerosis. Issues to consider
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