573095
STAT3 Inhibitor Peptide
Synonym(s):
Ac-PpYLKTK-OH, STAT3 Inhibitor I
Biochem/physiol Actions
STAT3
General description
A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 μM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.
Other Notes
Ac-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
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J Turkson et al.
The Journal of biological chemistry, 276(48), 45443-45455 (2001-10-02)
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic signaling proteins that participates in normal cellular responses to cytokines and growth factors. Frequently, however, constitutive activation of certain STAT family members, particularly Stat3, has accompanied a wide
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