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Merck
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Assay

≥95% (HPLC)

Quality Level

form

lyophilized solid

color

white

solubility

H2O: 1 mg/mL

General description

A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 μM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.

Biochem/physiol Actions

STAT3

Sequence

Ac-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Storage Class Code

10-13 - German Storage Class 10 to 13


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