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About This Item
Empirical Formula (Hill Notation):
C92H157N20O24P
Molecular Weight:
1958.32
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
STAT3 Inhibitor Peptide, Cell-Permeable, The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.
Quality Level
Assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Supplied as a trifluoroacetate salt.
A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Blocker of Stat3 activation
Blocker of Stat3 activation
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Sequence
H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
Other Notes
Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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