573108-M
STAT5 Inhibitor
The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.
Synonym(s):
STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
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About This Item
Empirical Formula (Hill Notation):
C16H11N3O3
CAS Number:
Molecular Weight:
293.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 25 mg/mL
storage temp.
2-8°C
SMILES string
N(\N=C\c2[c](c3c([o]c2)cccc3)=O)C(=O)c1cnccc1
InChI key
DAVIKTBRCQWOGT-GIJQJNRQSA-N
General description
A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
Other Notes
Muller, J., et al. 2008. ChemBioChem9, 723.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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