616455
TGF-β1, Human, Recombinant, CHO Cell Line
Synonym(s):
rhTGF-β1, Transforming Growth Factor-β1
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About This Item
UNSPSC Code:
12352202
Manufacturer/tradename:
Calbiochem®
assay
≥97% (SDS-PAGE)
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤1 EU/μg Endotoxin (EU/μg TGF-β1)
shipped in
ambient
storage temp.
−20°C
General description
Recombinant, human transforming growth factor-β1 expressed in CHO cells. Promotes apoptosis in resting human B lymphocytes, glioma cells, and trigeminal neurinomal cells. Induces the accumulation of extracellular matrix in various diseases.
Biochem/physiol Actions
ED₅₀ = 0.04-0.1 ng/ml
Physical form
Lyophilized from a sterile filtered solution in 50 µg BSA/µg TGF-β1, 35% acetonitrile, 0.1% TFA.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -20°C.
Reconstitute to a concentration ≥1 µg/ml in 4 mM sterile HCl containing ≥0.1% HSA or BSA.
Other Notes
Shibuya, H., et al. 1996. Science272, 1179.
Bottlinger, E.P., et al. 1995. Proc. Natl. Acad. Sci. USA93, 5877.
Lomo, J., et al. 1995. J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995. Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994. Am. J. Pathol. 144, 221.
Bottlinger, E.P., et al. 1995. Proc. Natl. Acad. Sci. USA93, 5877.
Lomo, J., et al. 1995. J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995. Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994. Am. J. Pathol. 144, 221.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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Nagat Frara et al.
Connective tissue research, 59(1), 30-44 (2017-04-13)
Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes.
Holly B Hindman et al.
Investigative ophthalmology & visual science, 51(4), 1935-1942 (2009-11-13)
Purpose. To characterize phenotypic differences between anterior and posterior corneal keratocytes after stimulation with the profibrotic agent transforming growth factor-beta1 (TGF-beta1) in vitro. Methods. Sixteen corneas from healthy felines were obtained immediately after death. Lamellar dissection was performed to separate
Hon Wai Koon et al.
The American journal of pathology, 177(5), 2300-2309 (2010-10-05)
Substance P (SP) and the neurokinin-1 receptor (NK-1R) are involved in the development of colitis and mucosal healing after colonic inflammation. We studied whether SP modulates colonic fibrosis by using a chronic model of trinitrobenzenesulfonic acid (TNBS)-induced colitis in wild-type
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 8070419025 | 04022536884615 |
| 8070410250 | 04022536393148 |
| 8070410005 | 04022536393131 |
| 8070411000 | 04022536393155 |
| P74370-20KG | 04061838124562 |
| P74370-25G | 04061838100627 |
| Y0000659 | 04061833804414 |
| W482900-100G | 04061837542077 |
| W482900-500G | 04061837542091 |
| 240338-50G | 04061838590367 |
| 83300-250ML | 04061833005545 |
| P74370-18KG | 04061829452452 |
| P74370-1KG | 04061834394761 |
| P74370-500G | 04061834394778 |
| 83300-1L | 04061833005538 |
| 616455-2UG | 04055977185874 |