616458
TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem
The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem, 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
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About This Item
Empirical Formula (Hill Notation):
C21H21NO4
CAS Number:
Molecular Weight:
351.40
UNSPSC Code:
12352200
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 10 mg/mL, ethanol: 2 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shimizu, T., et al. 2008. J. Med. Chem.51, 3326.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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Hanan Ahmed et al.
Cancers, 12(8) (2020-08-01)
The signalling pathways involved in metastasis of oral adenoid cancer cells (TYS) in response to cancer-associated fibroblasts (COM D24) and normal oral mucosal fibroblasts (MM1) was examined. Metastatic cell behaviour was observed by cell-scatter, 3-D-collagen gel migration, and 3-D-spheroid invasion