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Merck
CN

6.18030

Acetonitrile

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
UNSPSC Code:
12191502
Beilstein/REAXYS Number:
741857
MDL number:
MFCD00001878
Assay:
≥99.8% (GC)
Technique(s):
HPLC: suitable
Vapor pressure:
72.8 mmHg ( 20 °C)

Key Documents

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Quality Level

100

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.8% (GC)

form

liquid

autoignition temp.

973 °F

technique(s)

HPLC: suitable

mp

−45 °C (lit.)

solubility

water: soluble (1,000 g/l at 25 °C (77 °F))

suitability

suitable for chromatography

application(s)

general analytical

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General description

Acetonitrile is a highly polar, aprotic solvent known forits excellent ability to dissolve a wide range of analytes. It is commonly usedin reversed-phase HPLC due to its low viscosity and high purity, which enhancecolumn efficiency and resolution.Supelco® is a leading provider of high-quality HPLC solvents, targeting laboratories inthe pharmaceutical, environmental, and food safety sectors. The brand isrecognized for its commitment to precision, reliability, and innovation inanalytical chemistry. Supelco®′s extensive range of solvents ensures optimalperformance and reproducibility, making it a preferred choice for professionalsseeking consistent and accurate analytical results.

Application

  • Gradient Elution: Ideal for gradient elution techniques, enhancing the resolution and separation efficiency of complex mixtures.
  • Pharmaceutical Analysis: Frequently employed in the analysis of active pharmaceutical ingredients (APIs) and their impurities, ensuring compliance with regulatory standards.
  • Biological Sample Analysis: Used for the analysis of proteins, peptides, and metabolites in biological samples, facilitating accurate quantification and identification.
  • Environmental Monitoring: Applied in the HPLC analysis of environmental samples to detect and quantify contaminants in water, soil, and air.

Features and Benefits

  • High Purity: Formulated with minimal impurities, ensuring reliable and reproducible results essential for sensitive analytical applications.
  • Excellent UV Transparency: Provides optimal UV transmittance, facilitating accurate detection and enhancing sensitivity in HPLC analyses.
  • Low Evaporation Residue: Minimizes contamination risk, leading to cleaner separations and improved analytical reliability.
  • Batch-to-Batch Consistency: Ensures uniform quality and performance across different production batches, enhancing reproducibility and confidence in analytical results.

Legal Information

Supelco is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

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Anhydrous trifluoroacetic acid pretreatment converts insoluble polyglutamine peptides to soluble monomers
Burra G, et al.
Data in Brief, 5, 1066-1071 (2015)
Liquid chromatography method for simultaneous analysis of amino acids and biogenic amines in biological fluids with simultaneous gradient of pH and acetonitrile
Lozanov V, et al.
Journal of chromatography, 860(1), 92-97 (2007)
Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for screening of urine specimens for 100 analytes relevant in drug-facilitated crime (DFC)
Remane D, et al.
Analytical and Bioanalytical Chemistry, 406, 4411-4424 (2014)
Determination of ametoctradin residue in fruits and vegetables by modified quick, easy, cheap, effective, rugged, and safe method using ultra-performance liquid chromatography/tandem mass spectrometry
Hu M, et al.
Food Chemistry, 175, 395-400 (2015)

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