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Merck
CN

6.18598

Diethylamine

suitable for chromatography

Synonym(s):

Diethylamine

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About This Item

Linear Formula:
(C2H5)2NH
CAS Number:
109-89-7
Molecular Weight:
73.14
UNSPSC Code:
12352116
MDL number:
MFCD00009032

Key Documents

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SMILES string

N(CC)CC

InChI

1S/C4H11N/c1-3-5-4-2/h5H,3-4H2,1-2H3

InChI key

HPNMFZURTQLUMO-UHFFFAOYSA-N

suitability

suitable for chromatography

Quality Level

100

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General description

Diethylamine (DEA) is commonly used as an ​eluent additive in various chromatographic techniques, including reversed-phase high-performance liquid chromatography (HPLC), high pH reversed-phase preparative chromatography, and hydrophilic liquid chromatography (HILIC). It plays a crucial role in system efficiency and enhancing peak shape when used in column chromatography.

Application

Diethylamine can be used as a mobile phase modifierin the HILIC method for the simultaneous determination of paracetamol andmethionine in a soft capsule formulation.

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-14.8 °F - closed cup

flash_point_c

-26 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

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RP-HPLC ANALYSIS OF ACIDIC AND BASIC DRUGS IN SYSTEMS WITH DIETHYLAMINE AS ELUENTS ADDITIVE.
Petruczynik A, et al.
Acta Poloniae Pharmaceutica, 73(6), 1475-1485 (2016)
Separation of nadolol racemates by high pH reversed-phase preparative chromatography
Arafah RS, et al.
Separation and Purification Technology, 233, 116018-116018 (2020)
A new analytical methodology for a fast evaluation of semi-volatile polycyclic aromatic hydrocarbons in the vapor phase downstream of a diesel engine particulate filter
Journal of Chromatography A, 1218(7), 981-989 (2011)
Peak shape enhancement using diethylamine in hydrophilic liquid interaction chromatography: Application in simultaneous determination of methionine and paracetamol
BinhVN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 203, 114214-114214 (2021)

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