VEGF₁₆₄, Mouse, Recombinant, S. frugiperda

Recombinant, mouse VEGF₁₆₄ (164-amino acid splice variant of VEGF) expressed in S. frugiperda insect cells. It is the most abundant form of VEGF found in mice. VEGF₁₆₄ is a potent angiogenic factor and vascular permeability factor in vivo, as well as a chemoattractant for monocytes and endothelial cells. Forms a biological active homodimer. Evidence also suggests that it is biologically active as a heterodimer with other VEGF splice variants.

Recombinant, mouse VEGF₁₆₄ (164-amino acid splice variant of VEGF) expressed in S. frugiperda insect cells. The most abundant form in mice, VEGF₁₆₄ is a potent angiogenic factor and vascular permeability factor in vivo, as well as a chemoattractant for monocytes and endothelial cells. Forms a biologically active homodimer and evidence suggests that it is also biologically active as a heterodimer with other VEGF splice variants. Expression of VEGF₁₆₄ appears to be essential for normal bone development and vascularization.

ED₅₀ ≥1 ng/ml as measured by the stimulation of ³H-thymidine incorporation by human umbilical vein endothelial cells and bovine aortic endothelial cells. In vivo effects using the 13-day-old chick chorioallantoic membrane (CAM) assay can be seen between 0.5-4 µg

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.

Reconstitute in PBS or 50 mM acetic acid to a concentration ≥ 100 ng/µl.

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Grunstein, J., et al. 2000. Mol. Cell Biol.20, 7282.
Springer, M.L., et al. 2000. J. Gene Med.2, 279.

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Toxicity: Standard Handling (A)