Key Documents

View All Documentation

677181

Vincristine Sulfate

Name: Vincristine Sulfate
Brand: MM

≥98% (TLC), Microtuble disruptor, solid

Synonym(s):

Vincristine Sulfate, Apocynaceae sp.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₄₆H₅₆N₄O₁₀ · xH₂SO₄

CAS Number:

2068-78-2

Molecular Weight:

824.96 (free base basis)

UNSPSC Code:

12352210

NACRES:

NA.77

MDL number:

MFCD00084729

Assay:

≥98% (TLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Vincristine Sulfate, Apocynaceae sp., Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

Quality Level

100

description

Merck USA index - 14, 9986

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)([O-])[O-].[N+H]21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@@H]5[C@]64[C@H]7[N+H](CC6)CC=C[C@]7([C@H]([C@]5(O)C(=O)OC)OC(=O)C)CC)C=O)C(=O)OC

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChI key

AQTQHPDCURKLKT-JKDPCDLQSA-N

Description

General description

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Other Notes

Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H341,H361fd

pcodes

P202 - P264 - P270 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 2 Oral - Muta. 2 - Repr. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c