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681625

W-5, Hydrochloride

Name: W-5, Hydrochloride
Brand: MM

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

Synonym(s):

W-5, Hydrochloride, N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₂N₂O₂S · xHCl

CAS Number:

61714-25-8

Molecular Weight:

306.42 (free base basis)

MDL number:

MFCD00058043

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (NMR)

Form:

crystalline solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Quality Segment

100

assay

≥98% (NMR)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

solubility

DMSO: soluble, water: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCCCCCCN)c1c2c(ccc1)cccc2.[Cl-].[H+]

InChI

1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H

InChI key

HOCSVIGHWPLMFC-UHFFFAOYSA-N

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM) and myosin light chain kinase (IC₅₀ = 230 µM).

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 230 &microM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c