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About This Item

Empirical Formula (Hill Notation):
C14H18N2O2S · xHCl
CAS Number:
89108-46-3
Molecular Weight:
278.37 (free base basis)
MDL number:
MFCD00058052
UNSPSC Code:
12352200
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Quality Level

100

Assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 1 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H

InChI key

WYFVKUWCEVMLOL-UHFFFAOYSA-N

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM) and myosin light chain kinase (IC50 = 300 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Product does not compete with ATP.
Reversible: yes
Target IC50: 300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tanaka, T., et al. 1983. Pharmacol.26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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