681635
W-12, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 300 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM).
Synonym(s):
W-12, Hydrochloride, N-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl
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About This Item
Empirical Formula (Hill Notation):
C14H18N2O2S · xHCl
CAS Number:
Molecular Weight:
278.37 (free base basis)
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥97% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 1 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
InChI
1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H
InChI key
WYFVKUWCEVMLOL-UHFFFAOYSA-N
General description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM) and myosin light chain kinase (IC50 = 300 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Myosin light chain kinase (Mlck)
Myosin light chain kinase (Mlck)
Product does not compete with ATP.
Reversible: yes
Target IC50: 300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 681635-1MG | 04055977260151 |