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Merck
CN

681725-M

WY-14643 - CAS 50892-23-4 - Calbiochem

Synonym(s):

[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I

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assay

≥98% (HPLC)

form

crystalline solid

color

white

solubility

DMSO: 50 mg/mL

General description

A potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.

Biochem/physiol Actions

Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
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N Marx et al.
Circulation, 99(24), 3125-3131 (1999-06-22)
Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member
K Murakami et al.
Biochemical and biophysical research communications, 260(3), 609-613 (1999-07-15)
The alpha isoform of peroxisome proliferators-activated receptor (PPAR) is activated by fatty acids, their metabolites, and the fibrate class of lipid-lowering agents. To test the ability of these activators to directly bind the ligand-binding domain of human PPARalpha, we performed
C Dreyer et al.
Cell, 68(5), 879-887 (1992-03-06)
Three novel members of the Xenopus nuclear hormone receptor superfamily have been cloned. They are related to each other and similar to the group of receptors that includes those for thyroid hormones, retinoids, and vitamin D3. Their transcriptional activity is
J D Tugwood et al.
Annals of the New York Academy of Sciences, 804, 252-265 (1996-12-27)
We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of data to implicate the peroxisome proliferator-activated
H Keller et al.
Trends in endocrinology and metabolism: TEM, 4(9), 291-296 (1993-11-01)
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal
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