681725-M
WY-14643 - CAS 50892-23-4 - Calbiochem
Synonym(s):
[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
assay
≥98% (HPLC)
form
crystalline solid
color
white
solubility
DMSO: 50 mg/mL
General description
A potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
Biochem/physiol Actions
Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
J D Tugwood et al.
Annals of the New York Academy of Sciences, 804, 252-265 (1996-12-27)
We have been attempting to elucidate the molecular mechanisms through which peroxisome proliferators exert their pleiotropic effects, with particular emphasis on understanding why humans appear unresponsive to these compounds. There is a wealth of data to implicate the peroxisome proliferator-activated
I Issemann et al.
Nature, 347(6294), 645-650 (1990-10-18)
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help
H Keller et al.
Trends in endocrinology and metabolism: TEM, 4(9), 291-296 (1993-11-01)
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily like the steroid, thyroid, or retinoid hormone receptors, which are ligand-activated transcription factors regulating gene expression. PPARs mediate the induction of the enzymes of the peroxisomal and microsomal