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About This Item
Empirical Formula (Hill Notation):
C28H50N2O3
Molecular Weight:
462.71
UNSPSC Code:
12352200
Quality Level
Assay
≥90% (TLC)
form
film
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
clear
solubility
ethanol: 1 mg/mL
methanol: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A membrane-permeable, reversible blocker of IP3-mediated Ca2+ release (IC50 = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).
A reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).
Biochem/physiol Actions
Cell permeable: no
Primary Target
IP3-mediated Ca2+
IP3-mediated Ca2+
Product does not compete with ATP.
Reversible: yes
Target IC50: 648 nM in blocking IP3-mediated Ca2+ release
Preparation Note
Sonication may be required to achieve complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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