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AAVSERG-230K

MILLIPLEX® AAV Serotyping Panel

Simultaneously analyze up to 6 antibodies in a bead-based assay using Luminex technology, in human serum and plasma

Synonym(s):

AAV multiplex kit, AAV serotyping multiplex kit, Luminex® AAV assay, Luminex® AAV serotyping assay, Millipore AAV panel, Millipore AAV serotyping panel

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About This Item

UNSPSC Code:
41116126
NACRES:
NA.32

Product Name

MILLIPLEX® AAV Serotyping Panel,

Quality Level

200

description

Simultaneously analyze up to 6 antibodies in a bead-based assay using Luminex® technology, in human serum and plasma

species reactivity

human

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

input

plasma
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Adeno-associated virus (AAV) is recognized as a preferred vector for gene therapy due to its infectivity, versatility, and favorable safety profile. The various AAV serotypes exhibit distinct tissue specificities, transduction efficiencies, and immunogenicity, allowing for tailored approaches to gene therapy. While AAV generally has low immunogenicity, exposure to these viruses is common which leads to a high rate of seroprevalence in the general population. Pre-existing antibodies against AAV can challenge a gene therapy’s safety and efficacy making it essential to assess seroprevalence and immunogenicity in descriptive preclinical testing.

Application

MILLIPLEX® Qualified assays undergo rigourous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 anti-AAV antibodies in human serum and plasma.

Analytes included: anti-AAV1, anti-AAV2, anti-AAV5, anti-AAV6, anti-AAV8, anti-AAV9

Assay Characteristics: Refer to kit protocol for assay cross-reactivity and sensitivity.

Features and Benefits

  • Pioneering Technology: This first of its kind assay provides researchers provides a powerful tool to study immune responses to various AAV serotypes.
  • Multiplex Detection: Simultaneously detects antibodies to multiple AAV serotypes (AAV1, AAV2, AAV5, AAV6, AAV8, & AAV9) plus 4 assay control beads.
  • Complete Solution: Includes all necessary reagents and an intuitive protocol thus streamlining the workflow and reducing the need for multiple assays.
  • Demonstrated Precision and Specificity: Ensures high reliability with <10% intra-assay CV and <15% inter-assay CV, while specificity testing with serotype-specific control antibodies confirmed negligible cross-reactivity to non-specific antigens in most cases.

Preparation Note

Recommended storage for kit components is 2-8˚C.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

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Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 3

pictograms

Exclamation markEnvironment
GHS07,GHS09

Regulatory Information

新产品

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Protocol- AAVSERG-230K