13.3 kDa

Galanin is a neuropeptide which is not a member of any known family of neuropeptides, despite repeated efforts to discover related peptides. Its actions are mediated via Gi-protein-coupled receptors (GPCR’s) and ion channels, usually producing inhibition of secretion of a transmitter or hormone in the nervous and endocrine system. In many respects, these inhibitory actions of galanin remind us of those of gamma-aminobutyric acid (GABA) and of neuropeptide Y (NPY). Galanin coexists with GABA, noradrenaline, 5-hydroxytryptamine (5-HT), and NPY in several regions of the brain. Galanin and it’s receptor are over expressed in limbic region of the brain in patients suffering from Alzheimer′s disease. However it is not clear whether galanin exacerbates or is a protective response to the disease.

Synthetic Linear Peptide

Detect Galanin using this Anti-Galanin Antibody validated for use in IH(P).

Research Category
Neuroscience

Research Sub Category
Neurochemistry & Neurotrophins

Cat. # AB2233 recognizes Galanin

Reactivity with other species has not been determined.

Serum with 0.05% NaN3

Maintain at -20°C for up to 1 year from date of receipt.

Control
Rat Cerebellum Tissue

Routinely evaluated by Immunhistochemistry on rat cerebellum tissue.

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