ABN1385
Anti-RanBP2 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, Nuclear pore complex protein Nup358, Nucleoporin Nup358, Ran-binding protein 2, RanBP2, p270, ADANE, ANE1, IIAE3, Transformation-Related Protein 2, TRP1, TRP2
Sign In to View Organizational & Contract Pricing
Select a Size
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... RANBP2(5903)
General description
358.2 kDa calculated
RAN-binding protein 2 (RanBP2), also known as Nucleoporin Nup358 (Nup358), is encoded by the RANBP2 gene. RanBP2/Nup358 regulates functions of multiple cellular proteins through direct interactions via distinct domains. RanBP2/Nup358 binding partners include Ran GTPase, importin-beta, exportin-1/CRM1, red opsin, subunits of the proteasome, cox11, the kinesin-1 isoforms KIF5B and KIF5C, and E2 enzyme UBC9, where it functions as an E3 SUMO-protein ligase and facilitates subsequent SUMOylation of protein substrates such as RanGAP and SP100.
Immunogen
Epitope: Internal repeat IR1+2 domain (IR)
Recombinant protein corresponding to the internal repeat IR1+2 domain (IR) of human RanBP2.
Application
Anti-RanBP2 Antibody is an antibody against RanBP2 Antibody for use in Immunohistochemistry, Immunofluorescence.
Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected RanBP2 in mouse retina cells (Paulo Ferreira, Duke University)
Immunofluorescence Analysis: A representative lot detected in mouse retina of RanBP2 transgenic mice (Cho, K., et al. (2014). JBC. 1-31).
Immunofluorescence Analysis: A representative lot detected in mouse retina of RanBP2 transgenic mice (Cho, K., et al. (2014). JBC. 1-31).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Immunohistochemistry in human retina tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected RanBP2 in human retina tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected RanBP2 in human retina tissue.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jeeyoung Lee et al.
Cells, 10(9) (2021-09-29)
Cellular stress induces the formation of membraneless protein condensates in both the nucleus and cytoplasm. The nucleocytoplasmic transport of proteins mainly occurs through nuclear pore complexes (NPCs), whose efficiency is affected by various stress conditions. Here, we report that hyperosmotic
Yuki Ogawa et al.
Journal of cell science, 134(6) (2021-02-05)
Ranbp2 (also known as Nup358) is a member of the nucleoporin family, which constitutes the nuclear pore complex. Ranbp2 localizes at the nuclear membrane and was recently reported at the axon initial segment (AIS). However, we show that the anti-Ranbp2
Baojin Ding et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(9), 2024-2038 (2021-01-21)
DYT1 dystonia is a hereditary neurologic movement disorder characterized by uncontrollable muscle contractions. It is caused by a heterozygous mutation in Torsin A (TOR1A), a gene encoding a membrane-embedded ATPase. While animal models provide insights into disease mechanisms, significant species-dependent
Samuel S Pappas et al.
Human molecular genetics, 27(3), 407-420 (2017-12-01)
A critical challenge to deciphering the pathophysiology of neurodevelopmental disease is identifying which of the myriad abnormalities that emerge during CNS maturation persist to contribute to long-term brain dysfunction. Childhood-onset dystonia caused by a loss-of-function mutation in the AAA+ protein torsinA
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service