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Merck
CN

BI0158

Activator Reagent 0.5M ETT in Acetonitrile

0.5M ETT in Acetonitrile

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About This Item

UNSPSC Code:
41116006
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Product Name

Activator Reagent 0.5M ETT in Acetonitrile, 0.5M ETT in Acetonitrile

form

liquid

product line

Novabiochem®

reaction suitability

reaction type: Coupling Reactions
reagent type: catalyst

transition temp

flash point 5.6 °C

shipped in

ambient

storage temp.

2-30°C

Quality Level

Analysis Note

Color (APHA): 10 max
ETT [5-(Ethylthio)-1H-tetrazole] Molarity: 0.48-0.52M
Form: Clear liquid
Water (H2O): 60ppm max

Application

Ethyl thiotetrazole (ETT) in Acetonitrile can be used as an efficient activator reagent for the synthesis of oligonucleotides. This reagent is effective in the solid-phase synthesis of RNA oligonucleotides in terms of product yield in comparison with other reagents such as 4,5-dicyanoimidazole and 5-benzylthio-1H-tetrazole (BTT).

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

42.1 °F

flash_point_c

5.6 °C

Regulatory Information

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Stefanie Hoffmann et al.
Current protocols in nucleic acid chemistry, Chapter 4, Unit 4-Unit 4 (2011-09-09)
This unit describes the solid-phase synthesis and downstream processing for RNA oligonucleotides with a length of up to 40 to 50 nucleotides on a 1- to 4-mmol scale with subsequent conjugation to PEG using the L-RNA spiegelmer NOX-E36 as an

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