GHRT-89HK
Human Ghrelin (TOTAL) RIA
125I (<1.5 μCi, <56 kBq)
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About This Item
description
ED<sub>80</sub> = 395 ± 88 pg/mL ED<sub>50</sub> = 895 ± 177 pg/mL ED<sub>20</sub> = 2015 ± 382 pg/mL , analytes available: Ghrelin, for protein analysis
feature
accuracy 90–96%
species reactivity
human
sensitivity measuring range
100-10000 pg/mL
technique(s)
radioimmunoassay: suitable
UniProt accession no.
detection method
radioactive
Quality Level
General description
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.
Application
Analysis Note
Disclaimer
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3
target_organs
Central nervous system
Storage Class
3 - Flammable liquids
Regulatory Information
Certificates of Analysis (COA)
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