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Merck
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HCCBP3MAG-58K

MILLIPLEX® Human Circulating Cancer Biomarker Panel

Configurable Human Circulating Cancer Biomarker 8-Plex Panel 3

Synonym(s):

Luminex human circulating cancer biomarkers multiplex assay, Millipore human circulating cancer biomarkers multiplex kit, human cancer biomarker immunoassay panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
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species reactivity

human

Quality Level

assay range

accuracy: 74-126%, standard curve range: 0.004-3 ng/mL
(Galectin-3), standard curve range: 0.02-20 ng/mL
(Myeloperoxidase), standard curve range: 0.03-25 nM
(Sex Hormone Binding Globulin), standard curve range: 0.03-25 ng/mL
(Ferritin), standard curve range: 0.07-50 ng/mL
(Catalase, Fibroblast Activation Protein α), standard curve range: 0.1-75 ng/mL
(Melanoma Inhibitory Activity Protein), standard curve range: 0.27-200 ng/mL
(Cathepsin D, IGFBP3)

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Circulating cancer biomarkers give insight beyond intracellular oncogenesis and into how the body responds to the presence of a tumor, the dysregulation of homeostasis, and the relationship between a tumor and its environment. Multianalyte panels have become essential tools that enable researchers to measure cancer biomarkers simultaneously, teasing out these relationships and applying them to understand tumor biology.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 8 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: Cathepsin D, Ferritin, Fibroblast Activation Protein (FAP), Galectin-3, IGFBP3, Melanoma Inhibitory Activty Protein (MIA), Myeloperoxidase (MPO), Sex Hormone Binding Globulin (SHGB)

Note: When IGFBP3 is included in the assay, a larger sample dilution is required. The SHBG Standard was calibrated against WHO standard 08/266 and 250 ng/mL standard was equivalent to 25 nM of WHO standard.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive 8-Plex Analyte Kit: This panel facilitates the simultaneous quantification of eight essential biomarkers, including Galectin-3, Cathepsin D, and Fibroblast Activation Protein alpha (FAP), supporting extensive cancer research.
  • Advanced Luminex® xMAP®Technology: Utilizes a magnetic bead immunoassay approach that allows for quick and sensitive detection of multiple analytes, enhancing laboratory productivity while minimizing sample volume usage.
  • In-Depth Tumor Biology Insights: By enabling the measurement of multiple circulating biomarkers simultaneously, this panel helps researchers uncover critical insights into tumor biology and the body’s response to cancer.
  • All-in-One Kit Convenience: The kit is packaged with all necessary components, simplifying the setup process and reducing the potential for errors during preparation.
  • Recommended Sample Dilution: The assay recommends 25 μL of 1:50 diluted plasma or serum, or 25 μL of diluted tissue/cell lysate or culture supernatant per well, simplifying sample preparation.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

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Juan Pablo Hinestrosa et al.
Communications medicine, 2, 29-29 (2022-05-24)
Detecting cancer at early stages significantly increases patient survival rates. Because lethal solid tumors often produce few symptoms before progressing to advanced, metastatic disease, diagnosis frequently occurs when surgical resection is no longer curative. One promising approach to detect early-stage

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