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HCKP1-11K-PXBK17

MILLIPLEX® Human Immuno-Oncology Checkpoint Protein Panel

Bulk (Space Saver) Premixed Human Immuno-Oncology Checkpoint Protein 17-Plex Panel 1

Synonym(s):

17-Plex Immuno-Oncology Kit, Human Checkpoint Protein Panel, Immuno-Oncology 17-Plex Panel

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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Product Name

MILLIPLEX® Human Immuno-Oncology Checkpoint Protein Panel,

description

Bulk (Space Saver) Premixed Human Immuno-Oncology Checkpoint Protein 17-Plex Panel 1

manufacturer/tradename

Milliplex®

species reactivity

human

packaging

pkg of 1 ea

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Immune checkpoint proteins are regulators of immune activation and play a key role in maintaining immune homeostasis, preventing autoimmunity, and are involved in cancer immune escape. These immune system molecules demonstrate the ability to act both as agonists (co-stimulatory checkpoint molecules) or antagonists (co-inhibitory checkpoint molecules) of immune response. Immune checkpoint inhibitor drugs targeting inhibitory immune checkpoint proteins, such as CTLA-4 and PD-L1, have demonstrated efficacy in cancer immunotherapy by improving the antitumor immune response and saving lives in the treatment of many malignancies. Immune checkpoint proteins may express on immune cells and/or tumor cells as activating receptors or inhibitory receptors. Many immune checkpoint proteins are also expressed as soluble forms in circulation and in the tumor and tumor microenvironment and are putative biomarkers for immunotherapy in various diseases including cancer.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 17 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: BTLA (B- and T-lymphocyte attenuator), CD27 (Cluster of differentiation 27), CD28 (Cluster of differentiation 28), CD40 (Cluster of differentiation 40), CD80/B7-1 (Cluster of differentiation 80/B7-1), CD86/B7-2 (Cluster of differentiation 86/B7-2), CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), GITRL (Ligand for receptor TNFRSF18/AITR/GITR), GITR (Glucocorticoid-induced TNFR-related protein), HVEM (Herpesvirus entry mediator), ICOS (Inducible T-cell costimulator), LAG-3 (Lymphocyte-activation gene 3), PD-L1 (Programmed death-ligand 1), PD-L2 (Programmed death-ligand 2), PD-1 (Programmed cell death protein 1), TIM-3 (T-cell immunoglobulin and mucin-domain containing-3), TLR-2 (Toll like receptor 2)

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • 17-Plex Immune Checkpoint Profiling: Streamline research with simultaneous detection of 17 biomarkers, including PD-L1, LAG-3, and TIM-3, in one run—ideal for studying immune evasion, therapy response, and tumor microenvironment dynamics.
  • Bulk Packaging Efficiency: Space-saving bulk kits minimize storage requirements and lower per-test costs for high-throughput labs or long-term studies.
  • Scalable Workflows: Compatible with high-throughput systems, enabling large cohort studies or drug screening.
  • Minimal Cross-Reactivity: Antibodies show negligible cross-reactivity, ensuring high specificity and reliable data.
  • Broad Sample Compatibility: Validated for serum, plasma, and tissue culture supernatants (neat or diluted), supporting diverse experimental designs.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

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