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MABN501

Sigma-Aldrich

Anti-SUR1 Antibody, clone N289/16

clone N289/16, from mouse

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Synonym(s):
ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N289/16, monoclonal

species reactivity

human, mouse

species reactivity (predicted by homology)

rat (immunogen homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_037171

UniProt accession no.

Q09429

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ABCC8(6833)

General description

Sulfonylurea receptor 1 (SUR1) is also called ATP-binding cassette sub-family C member 8, and is a member of the ABC transporter superfamily. SUR1 is a putative subunit of the beta-cell ATP-sensitive potassium channel (KATP) and functions as a regulator of ATP-sensitive K+ channels and insulin release.

Specificity

This antibody recognizes the C-terminus of SUR1. Representative lot deteted Sur1 in crude brain membrane preparations
in SUR1 wild-type (WT) mouse cell lysate, and demonstrated a loss of signal in SUR1 knockout (KO) mouse cell lysate (Prof. J. Trimmer, University of California, Davis.).

Immunogen

Recombinant protein corresponding to the C-terminus of rat SUR1.

Application

Anti-SUR1 Antibody, clone N289/16 is a highly specific mouse monoclonal antibody, that targets SUR & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SUR1 in human thalamus tissue.

Quality

Evaluated by Western Blotting in mouse hypothalamus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SUR1 in 10 µg of mouse hypothalamus tissue lysate.

Target description

~ 180 kDa observed

Physical form

Format: Purified

Analysis Note

Control
Mouse hypothalamus tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Ching-Han Lin et al.
The Journal of biological chemistry, 298(5), 101904-101904 (2022-04-11)
Pancreatic β-cells express ATP-sensitive potassium (KATP) channels, consisting of octamer complexes containing four sulfonylurea receptor 1 (SUR1) and four Kir6.2 subunits. Loss of KATP channel function causes persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a rare but debilitating condition if not

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