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Merck
CN

PC04

Sigma-Aldrich

Anti-c-ErbB2/c-Neu (Ab-1) (866-880) Rabbit pAb

liquid, Calbiochem®

Synonym(s):

Anti-HER2, Anti-c-Neu, Anti-Erythroblastosis Virus

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

antibody product type

primary antibodies

clone

polyclonal

form

liquid

does not contain

preservative

species reactivity

human, rat

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

General description

This product has been discontinued.



Recognizes the ~185 kDa c-ErbB2/c-Neu protein in Sk-BR-3 cells.

Purified rabbit polyclonal antibody. Recognizes the ~185 kDa native and denatured forms of c-ErbB2/c-Neu.

Immunogen

a synthetic peptide (LARLLDIDETEYHAD) corresponding to amino acids 866-880 from the kinase domain of human c-Neu

Application

Immunoblotting (1-5 µg/ml)

Immunofluorescence (1-5 µg/ml)

Immunoprecipitation (1-2 µg/sample)

Paraffin Sections (1-10 µg/ml, saponin pre-treatment required, see application references)

Packaging

Please refer to vial label for lot-specific concentration.

Analysis Note

Negative Control
Normal human fibroblasts
Positive Control
SK-BR-3 cells

Other Notes

Antibody should be titrated for optimal results in individual sample types.
Di Fiore, P.P., et al. 1987. Science237, 178.
Slamon, D.J., et al. 1987. Science235, 177.
Varley, J.M., et al. 1987. Oncogene1, 423.
Bargmann, C.I., et al. 1986. Nature319 226.
Yamamoto, T., et al. 1986. Nature319, 230.
Blick, M., et al. 1984. Blood64, 1234.
Schwab, M., et al. 1984. Cold Spring Harbor Laboratory2, 215.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Regulatory Information

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Certificates of Analysis (COA)

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P P Di Fiore et al.
Science (New York, N.Y.), 237(4811), 178-182 (1987-07-10)
A wide variety of human tumors contain an amplified or overexpressed erbB-2 gene, which encodes a growth factor receptor-like protein. When erbB-2 complementary DNA was expressed in NIH/3T3 cells under the control of the SV40 promoter, the gene lacked transforming
Jaime Lindsay et al.
Clinical and translational science, 1(2), 107-115 (2008-09-01)
The ErbB2 (Her2/neu epidermal growth receptor family) oncogene is overexpressed in 30% to 40% of human breast cancers. Cyclin D1 is the regulatory subunit of the holoenzyme that phosphorylates and inactivates the retinoblastoma (pRb) tumor suppressor and is an essential
C I Bargmann et al.
Nature, 319(6050), 226-230 (1986-01-16)
The neu oncogene is repeatedly activated in neuro- and glioblastomas derived by transplacental mutagenesis of the BDIX strain of rat with ethylnitrosourea. Foci induced by the DNAs from such tumours on NIH 3T3 cells contain the neu oncogene and an
T Yamamoto et al.
Nature, 319(6050), 230-234 (1986-01-16)
A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the human genome, maps to human chromosome 17 at q21 (ref. 40), and seems to encode a polypeptide with a kinase domain that is highly homologous with, but distinct from
M Blick et al.
Blood, 64(6), 1234-1239 (1984-12-01)
The transforming genes of retroviruses (v-onc) are derived from normal cellular genes referred to as proto-oncogenes. These cellular genes have the capacity for conversion to oncogenes (c-onc) that are capable of inducing or maintaining the transformed state when they are
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