PC344
Anti-Netrin-1 (Ab-1) (557-568) Rabbit pAb
liquid, Calbiochem®
Product Name
Anti-Netrin-1 (Ab-1) (557-568) Rabbit pAb, liquid, Calbiochem®
biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
mouse
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
isotype
IgG
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Analysis Note
Positive Control
Mouse brain tissue
Mouse brain tissue
Application
Immunoblotting (1 g/ml)
Frozen Sections (not recommended)
Disclaimer
Toxicity: Standard Handling (A)
General description
Purified rabbit polyclonal antibody. Recognizes the ~60 kDa netrin-1 protein.
Recognizes the ~70 kDa netrin-1 protein in embryonic mouse brain tissue.
Immunogen
Mouse
a synthetic peptide (LGNAEDSPDQSG) corresponding to amino acids 557-568 of mouse netrin-1, conjugated to KLH
Other Notes
Immunoblotting was performed using brain tissue from various developmental stages. Netrin-1 protein is enriched in embryonic neural tissue. Antibody should be titrated for optimal results in individual systems. For immunohistochemistry applications, Anti-Netrin-1 (Ab-2) Rabbit pAb is also available (Cat. No. PC364-100 µg).
Varela-Echavarria, A., and Guthrie, S. 1997. Genes and Dev.11, 545.
Harris, R., et al. 1996. Neuron17, 217.
Keino-Masu, K., et al. 1996. Cell87, 175.
Mitchell, K.J., et al. 1996. Neuron17, 203.
Serafini, T., et al. 1996. Cell87, 1001.
Tessier-Lavigne, M. and Goodman, C.S. 1996. Science274, 1123.
Kennedy, T.E., et al. 1994. Cell78, 425.
Serafini, T., et al. 1994. Cell78, 409.
Ishii, N., et al. 1992. Neuron9, 873.
Hedgecock, E.M., et al. 1990. Neuron4, 61.
Harris, R., et al. 1996. Neuron17, 217.
Keino-Masu, K., et al. 1996. Cell87, 175.
Mitchell, K.J., et al. 1996. Neuron17, 203.
Serafini, T., et al. 1996. Cell87, 1001.
Tessier-Lavigne, M. and Goodman, C.S. 1996. Science274, 1123.
Kennedy, T.E., et al. 1994. Cell78, 425.
Serafini, T., et al. 1994. Cell78, 409.
Ishii, N., et al. 1992. Neuron9, 873.
Hedgecock, E.M., et al. 1990. Neuron4, 61.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 0.05 M sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Regulatory Information
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John J White et al.
Journal of nephrology, 26(6), 1055-1064 (2013-09-21)
Netrin-1 was recently identified as an early diagnostic biomarker of acute kidney injury. However, its usefulness for early diagnosis of chronic kidney disease (CKD) is unknown. The current study evaluated whether these proteins are increased in urine from experimental animals
Weiwei Wang et al.
American journal of physiology. Renal physiology, 294(4), F739-F747 (2008-01-25)
Endogenous mechanisms exist to limit inflammation. One such molecule is netrin. This study examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin in preventing renal inflammation and injury. All three isoforms of netrin (1, 3
Liqing Wang et al.
The Journal of comparative neurology, 525(13), 2915-2928 (2017-05-26)
Using Nogo antibodies with defined binding specificity, Nogo-B, but not Nogo-A, was localized on radial glia in the floor plate of mouse embryos. The presence of Nogo-B was confirmed in Nogo-A knockout mice. In explant cultures of embryonic day (E)
W Brian Reeves et al.
American journal of physiology. Renal physiology, 294(4), F731-F738 (2008-02-01)
Acute kidney injury is an important complication in hospitalized patients often diagnosed late and associated with high mortality and morbidity. Although biomarkers for nephrotoxicity are available, they often lack sensitivity and specificity for detecting tubular injury. Netrin-1 is a laminin-like
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