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10105678001

Roche

Glutathione Reductase (GR)

Name: Glutathione Reductase (GR)
Brand: ROCHE

from yeast

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About This Item

EC Number:

1.6.4.2 (BRENDA, IUBMB)

UNSPSC Code:

12352200

biological source

yeast

form

suspension

specific activity

~120 units/mg protein (At 25 °C with oxidized glutathione as the substrate; standardized with BSA.)

packaging

pkg of 1 mL (5 mg)

manufacturer/tradename

Roche

storage temp.

2-8°C

General description

Glutathione:NADP⁺ oxidoreductase

Application

Glutathione reductase (GR) has been used for the reduction of GSSG (glutathione disulfide) to GSH (glutathione).

Biochem/physiol Actions

Glutathione Reductase (GR) is a NADPH-dependent flavoprotein that catalyzes the reduction of glutathione disulfide (GSSG) to glutathione (GSH). It is involved in the maintenance of glutathione levels, which is important for oxidation–reduction processes, detoxication and several other cellular functions. In yeast, GR protects the cells from oxidative stress and is transcriptionally regulated by yAP-1 (yes-associated protein 1) protein.

Quality

Contaminants: <0.01% NADPH oxidase and 6-PGDH each, <0.1% G6P-DH

Physical form

Suspension in 3.2 M ammonium sulfate solution, pH approximately 6

Preparation Note

The ammonium sulfate suspension is stable at 2 to 8 °C until the expiration date printed on the label. It may be used directly in assays for glutathione.

Activator: EDTA prevents the formation of enzyme aggregates. Phosphate stimulates the NADH-dependent reaction.

Other Notes

For life science research only. Not for use in diagnostic procedures.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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