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Merck
CN

10378461001

Roche

Chromozym PL

90%, powder, pkg of 20 mg

Synonym(s):

chromogenic substrate

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54
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assay

90%

form

powder

packaging

pkg of 20 mg

manufacturer/tradename

Roche

storage temp.

room temp

General description

Chromozym® PL is a chromogenic substrate. It is a synthetic tripeptide substrate and is more plasmin-specific.

Application

Chromozym® PL has been used:
  • to determine the plasmin enzymatic activity using human umbilical vein endothelial cells (HUVEC) cell extracts
  • as a chromogenic substrate for proteolytic activity in murine lung homogenates
  • as a substrate of plasmin in plasminogen activation assays

Physical form

Powder

Preparation Note

Working concentration: Approximately 0.3 to 0.6 mM
Storage conditions (working solution): 2 to 8 °C
A substrate solution (3 mM) is stable for at least two weeks if stored at 2 to 8 °C. Avoid contamination with germs.

Analysis Note

Purity: 90% Tosyl-Gly-Pro-Lys-4-nitranilide acetate (enzymatic)
Contaminant: <0.5% free 4-nitraniline
Formula: C26H35N6O7SCOOCH3

Other Notes

For life science research only. Not for use in diagnostic procedures.
Tosyl-glycyl-polyl-lysine-4-nitranilide-acetate

Legal Information

Chromozym is a registered trademark of Pentapharm AG, Basel


Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Jessica L Bradshaw et al.
mSphere, 3(3) (2018-05-04)
Pneumonia is a pulmonary disease affecting people of all ages and is consistently a leading cause of childhood mortality and adult hospitalizations. Streptococcus pneumoniae and Pseudomonas aeruginosa are major lung pathogens commonly associated with community-acquired and nosocomial pneumonia. Additionally, mixed
C Kluft et al.
Blood, 59(6), 1169-1180 (1982-06-01)
This study concerns a case of congenital homozygous deficiency in alpha 2-antiplasmin associated with a severe hemorrhagic diathesis. Heterozygous family members also show a mild bleeding tendency. The propositus is a 17-yr-old male born of white parents and showing a
L S Engel et al.
The Journal of biological chemistry, 273(27), 16792-16797 (1998-06-27)
Comparisons of virulence between a Pseudomonas parent strain and an isogenic mutant devoid of protease IV have demonstrated a significant role for this enzyme during infection. We have characterized purified Pseudomonas aeruginosa protease IV in terms of its biochemical and



Global Trade Item Number

SKUGTIN
1037846100104061838670861