00251
Fumarylacetone
≥95.0% (GC)
Synonym(s):
(2E)-4,6-Dioxo-2-heptenoic acid
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About This Item
Empirical Formula (Hill Notation):
C7H8O4
CAS Number:
Molecular Weight:
156.14
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
1907125
InChI
1S/C7H6O3/c8-5-1-2-6(9)4-7(10)3-5/h1-2H,3-4H2
SMILES string
CC(CC(/C=C/C(O)=O)=O)=O
InChI key
LRBCDZWXQXOVTN-UHFFFAOYSA-N
assay
≥95.0% (GC)
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Metabolite of tyrosine catabolic pathway
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Albert L Shroads et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 808(2), 153-161 (2004-07-21)
Tyrosine and many of its catabolites play significant roles in the in the toxicity associated with acquired and congenital forms of hypertyrosinemia. We now report a specific and sensitive GC/MS method for the simultaneous determination of tyrosine metabolites maleylacetone (MA)
Hoffman B M Lantum et al.
Chemical research in toxicology, 15(5), 707-716 (2002-05-23)
Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate or maleylacetone (MA) to fumarylacetoacetate or fumarylacetone (FA), respectively. GSTZ1-1 also catalyzes the glutathione-dependent biotransformation of a range of alpha-haloacids, including dichloroacetic acid. The objective of this study was to
C Laberge et al.
Advances in experimental medicine and biology, 206, 209-221 (1986-01-01)
Review of the literature of the past 40 years on tyrosine and its toxicity shows that no direct link between this aromatic amino acid and carcinogenesis has been well established. Ten years ago, studies of tyrosine toxicity in mice suggested
Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.
H B Lantum et al.
Advances in experimental medicine and biology, 500, 339-342 (2002-01-05)
J M Fernández-Cañón et al.
The Journal of biological chemistry, 273(1), 329-337 (1998-02-07)
We have previously used Aspergillus nidulans as a fungal model for human phenylalanine catabolism. This model was crucial for our characterization of the human gene involved in alcaptonuria. We use here an identical approach to characterize at the cDNA level
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