Skip to Content
Merck
CN

00881

(±)-4-Hydroxypropranolol hydrochloride

analytical standard

Synonym(s):

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride, 4′-Hydroxypropranolol hydrochloride, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-1-naphthalenol hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C16H21NO3·HCl
CAS Number:
14133-90-5
Molecular Weight:
311.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329747156
MDL number:
MFCD06656370
Beilstein/REAXYS Number:
4036845

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H

SMILES string

CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl

InChI key

ROUJENUXWIFONU-UHFFFAOYSA-N

grade

analytical standard

assay

≥98.5% (AT), ≥98.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

Related Categories

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCL5746
BCCH1537
BCCC6246
BCBV6968

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Wenying Jian et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(31), 3267-3276 (2010-11-09)
In recent years, increasing emphasis has been placed on quantitative characterization of drug metabolites for better insight into the correlation between metabolite exposure and toxicological observations or pharmacological efficacy. One common strategy for metabolite quantitation is to adopt the stable
Keyller Bastos Borges et al.
Electrophoresis, 30(16), 2874-2881 (2009-08-20)
An experimental design optimization (Box-Behnken design, BBD) was used to develop a CE method for the simultaneous resolution of propranolol (Prop) and 4-hydroxypropranolol enantiomers and acetaminophen (internal standard). The method was optimized using an uncoated fused silica capillary, carboxymethyl-beta-cyclodextrin (CM-beta-CD)
K Rowland et al.
British journal of clinical pharmacology, 38(1), 9-14 (1994-07-01)
1. The 4-hydroxylation of propranolol by rat and human liver microsomes is associated with formation of a chemically reactive species which binds irreversibly to cytochrome P4502D6 (CYP2D6) destroying its catalytic function. Therefore, the effect of propranolol treatment (80 mg twice
F Moriya et al.
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence, 26(5), 360-366 (1991-10-01)
Effect of ethanol administration on blood propranolol concentration (BPC) was investigated with rats. By oral administration of 20 mg/kg propranolol hydrochloride together with 1.5 g/kg of ethanol, it was suggested that there might be an increase in blood 4-hydroxypropranolol concentration
Y Masubuchi et al.
Biochemical pharmacology, 43(4), 757-762 (1992-02-18)
The mechanism of selective inhibition of propranolol hydroxylations after multiple administration of the drug was investigated by metabolic inhibition studies in rat liver microsomes. The time course of irreversible binding of a reactive metabolic intermediate(s) of propranolol to liver microsomal
View All Related Papers

Related Content

最新推出的满足海关审查要求的标准物质

默克Supelco®标准物质不断推出或更新满足海关及法规要求的标准物质。每年我们约有上百种的新CRM或标准物质上市，在此我们尽可能多的列出满足海关及法规要求的标准物质。

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service