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02412

Ethanolamine solution

suitable for peptide synthesis, ~74% (T), ~70% in methanol

Synonym(s):

2-Aminoethanol

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About This Item

Empirical Formula (Hill Notation):
C2H7NO
CAS Number:
141-43-5
Molecular Weight:
61.08
PubChem Substance ID:
329747430
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
3535200
MDL number:
MFCD00008183
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assay

~74% (T)

concentration

~70% in methanol

refractive index

n20/D 1.422

solubility

heptane: soluble less than 0.1%, carbon tetrachloride: soluble 0.2%, benzene: soluble 1.4%, diethyl ether: soluble 2.1%, H2O: miscible, acetone: miscible, alcohol: miscible, chloroform: miscible, hexane: insoluble, methanol: miscible

application(s)

peptide synthesis

SMILES string

NCCO

InChI

1S/C2H7NO/c3-1-2-4/h4H,1-3H2

InChI key

HZAXFHJVJLSVMW-UHFFFAOYSA-N

Application

Ethanolamine solution was used as a medium supplement utilized in proliferation assay. The product was used for preparing the transferrin conjugate which in turn was used for studying whether adriamycin are cytotoxic without intercalating nuclear DNA. Further, ethanolamine along with [9,10(n)-3H]oleate synthesizes [3H]OEA (Oleoylethanolamide).

Biochem/physiol Actions

Ethanolamine is a compound derived from cell membranes and is utilized as a source of carbon and/or nitrogen. It can regulate the expression of genes that encodes components in interkingdom signaling to activate virulence gene expression in Escherichia coli O157:H7 (EHEC). It also serves as a STAT-3-dependent cardioprotective agent.

Preparation Note

Ethanolamine solution is miscible in methanol, acetone, water, chloroform and glycerine. The product is immiscible in solvent hexane, fixed oils as well as ether. Additionally, the product is soluble in 1.4% benzene, 2.1% ether, 0.2% carbon tetrachloride and less than 0.1% heptane at 25 degrees c.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 1 - STOT SE 3

target_organs

Eyes,Central nervous system, Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

89.6 °F - closed cup

flash_point_c

32 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Melissa M Kendall et al.
mBio, 3(3), doi:10-doi:10 (2012-05-17)
Bacterial pathogens must be able to both recognize suitable niches within the host for colonization and successfully compete with commensal flora for nutrients in order to establish infection. Ethanolamine (EA) is a major component of mammalian and bacterial membranes and
K Barabas et al.
The Journal of biological chemistry, 267(13), 9437-9442 (1992-05-05)
Studies of the biological chemistry of most anticancer drugs have revealed their cytotoxicity is expressed after the drugs have entered cells. It is thought that anthracycline antitumor drugs exert their cytotoxicity by entering cells, diffusing into nuclei, and inhibiting topoisomerase
Mie Julin Nielsen et al.
Journal of lipid research, 45(6), 1027-1029 (2004-04-03)
Oleoylethanolamide (OEA) may be an endogenous regulator of food intake, and intraperitoneal injection of this compound decreases food intake in 24 h-starved rats. It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract
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Global Trade Item Number

SKUGTIN
V900581-500G04061831837414
PHR3330-50MG04065267470085
135577-5G04061838730725
V900581-100G04061831827828
135577-100G04061838730701
135577-500G04061838730718