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Merck
CN

02412

Ethanolamine solution

suitable for peptide synthesis, ~74% (T), ~70% in methanol

Synonym(s):

2-Aminoethanol

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About This Item

Empirical Formula (Hill Notation):
C2H7NO
CAS Number:
141-43-5
Molecular Weight:
61.08
PubChem Substance ID:
329747430
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
3535200
MDL number:
MFCD00008183

Key Documents

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SMILES string

NCCO

InChI

1S/C2H7NO/c3-1-2-4/h4H,1-3H2

InChI key

HZAXFHJVJLSVMW-UHFFFAOYSA-N

assay

~74% (T)

concentration

~70% in methanol

refractive index

n20/D 1.422

solubility

heptane: soluble less than 0.1%, carbon tetrachloride: soluble 0.2%, benzene: soluble 1.4%, diethyl ether: soluble 2.1%, H2O: miscible, acetone: miscible, alcohol: miscible, chloroform: miscible, hexane: insoluble, methanol: miscible

application(s)

peptide synthesis

Application

Ethanolamine solution was used as a medium supplement utilized in proliferation assay. The product was used for preparing the transferrin conjugate which in turn was used for studying whether adriamycin are cytotoxic without intercalating nuclear DNA. Further, ethanolamine along with [9,10(n)-3H]oleate synthesizes [3H]OEA (Oleoylethanolamide).

Biochem/physiol Actions

Ethanolamine is a compound derived from cell membranes and is utilized as a source of carbon and/or nitrogen. It can regulate the expression of genes that encodes components in interkingdom signaling to activate virulence gene expression in Escherichia coli O157:H7 (EHEC). It also serves as a STAT-3-dependent cardioprotective agent.

Preparation Note

Ethanolamine solution is miscible in methanol, acetone, water, chloroform and glycerine. The product is immiscible in solvent hexane, fixed oils as well as ether. Additionally, the product is soluble in 1.4% benzene, 2.1% ether, 0.2% carbon tetrachloride and less than 0.1% heptane at 25 degrees c.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 1 - STOT SE 3

target_organs

Eyes,Central nervous system, Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

89.6 °F - closed cup

flash_point_c

32 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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K Barabas et al.
The Journal of biological chemistry, 267(13), 9437-9442 (1992-05-05)
Studies of the biological chemistry of most anticancer drugs have revealed their cytotoxicity is expressed after the drugs have entered cells. It is thought that anthracycline antitumor drugs exert their cytotoxicity by entering cells, diffusing into nuclei, and inhibiting topoisomerase
Melissa M Kendall et al.
mBio, 3(3), doi:10-doi:10 (2012-05-17)
Bacterial pathogens must be able to both recognize suitable niches within the host for colonization and successfully compete with commensal flora for nutrients in order to establish infection. Ethanolamine (EA) is a major component of mammalian and bacterial membranes and
Mie Julin Nielsen et al.
Journal of lipid research, 45(6), 1027-1029 (2004-04-03)
Oleoylethanolamide (OEA) may be an endogenous regulator of food intake, and intraperitoneal injection of this compound decreases food intake in 24 h-starved rats. It is generally believed that this kind of lipid amide is rapidly catabolized in the gastrointestinal tract
Roisin F Kelly et al.
Basic research in cardiology, 105(6), 763-770 (2010-10-13)
Ethanolamine is a biogenic amine found naturally in the body as part of membrane lipids and as a metabolite of the cardioprotective substances, sphingosine-1-phosphate (S1P) and anandamide. In the brain, ethanolamine, formed from the breakdown of anandamide protects against ischaemic
J S Rubin et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(3), 802-806 (1989-02-01)
A growth factor specific for epithelial cells was identified in conditioned medium of a human embryonic lung fibroblast cell line. The factor, provisionally termed keratinocyte growth factor (KGF) because of its predominant activity on this cell type, was purified to
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