03557
Poly(ethylene glycol)
tested according to Ph. Eur., 35,000
Synonym(s):
Macrogol 35,000, PEG
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About This Item
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12161900
MDL number:
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
agency
tested according to Ph. Eur.
form
powder
mol wt
~35000
solubility
aliphatic hydrocarbons: slightly soluble, organic solvents: soluble
application(s)
pharmaceutical (small molecule)
Quality Level
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Application
Poly (ethylene glycol) can be used as a test compound utilized in the overproduction and purification of recombinant Lactobacillus reuteri LrNDT. It can also be used for concentrating the mutants with lower secretion levels used in ELISAs for the quantitation of shgp190 and of the LIF/shgp190 complexes.
Biochem/physiol Actions
Polyethylene glycol (PEG) is a condensation polymer of ethylene oxide and water. It enhances the refolding of extracted proteins. This enables characterization of crystallized proteins.
Preparation Note
Poly(ethylene glycol) dissolves in many organic solvents and is readily soluble in aromatic hydrocarbons. It also slightly dissolves in aliphatic hydrocarbons.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
281.5 °F - closed cup
flash_point_c
138.6 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Juliette Bitard et al.
The Journal of biological chemistry, 278(18), 16253-16261 (2003-02-26)
The leukemia inhibitory factor (LIF) receptor comprises the low affinity binding chain gp190 and the high affinity converter gp130. The ectodomain of gp190 is among the most complex in the hematopoietin receptor family, because it contains two typical cytokine receptor
Jesús Fernández-Lucas et al.
Applied and environmental microbiology, 76(5), 1462-1470 (2010-01-06)
A novel type II nucleoside 2'-deoxyribosyltransferase from Lactobacillus reuteri (LrNDT) has been cloned and overexpressed in Escherichia coli. The recombinant LrNDT has been structural and functionally characterized. Sedimentation equilibrium analysis revealed a homohexameric molecule of 114 kDa. Circular dichroism studies
J L Cleland et al.
The Journal of biological chemistry, 267(19), 13327-13334 (1992-07-05)
Polyethylene glycol (PEG) inhibited aggregation during refolding of bovine carbonic anhydrase B (CAB) through the formation of a nonassociating PEG-intermediate complex. Stoichiometric concentrations of PEG were required for complete recovery of active protein during refolding at aggregating conditions. For example
J L Cleland et al.
Bio/technology (Nature Publishing Company), 10(9), 1013-1019 (1992-09-01)
Previous studies on the refolding of recombinant bovine carbonic anhydrase B (CAB) indicated that polyethylene glycol (PEG) significantly enhanced the recovery of active protein by reducing aggregation. To further test the ability of PEG to enhance refolding, three recombinant human
Mark A Rice et al.
Acta biomaterialia, 5(1), 152-161 (2008-09-17)
Ultrasound has potential as a non-destructive analytical technique to provide real-time online assessments of matrix evolution in cell-hydrogel constructs used in tissue engineering. In these studies, chondrocytes were encapsulated in poly(ethylene glycol) hydrogels, and gel degradation was manipulated to provide
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