03583
1-(Boc-amino)cyclopentanecarboxylic acid
≥98.0% (TLC)
Synonym(s):
Boc-cycloleucine
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About This Item
Linear Formula:
(CH3)3CO2CNHC5H8CO2H
CAS Number:
Molecular Weight:
229.27
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
2734412
MDL number:
SMILES string
CC(C)(C)OC(=O)NC1(CCCC1)C(O)=O
InChI
1S/C11H19NO4/c1-10(2,3)16-9(15)12-11(8(13)14)6-4-5-7-11/h4-7H2,1-3H3,(H,12,15)(H,13,14)
InChI key
YBZCSKVLXBOFSL-UHFFFAOYSA-N
assay
≥98.0% (TLC)
form
powder with small lumps
color
white
mp
129-135 °C
application(s)
peptide synthesis
Other Notes
This bulky cycloleucine imparts protection against hydrolysis to neighbouring amide bonds. Synthesis of conformationally restricted analogs.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C A Fink et al.
Journal of medicinal chemistry, 38(26), 5023-5030 (1995-12-22)
Dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP, EC 3.4.24.11) and angiotensin-I converting enzyme, have been the focus of much clinical interest for the treatment of hypertension and congestive heart failure. A novel series of alpha-thio dipeptides containing
N Fabiano et al.
International journal of peptide and protein research, 42(5), 459-465 (1993-11-01)
The synthesis, physical and analytical characterization, and crystal-state structural analysis by X-ray diffraction of three analogues of the N alpha-acylated tripeptide amide tail of oxytocin, each containing a cyclic C alpha, alpha-disubstituted glycine at position 2, have been performed. The
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