05022
N,N-Dimethylglycine
LiChropur™, ≥99% (NT)
Synonym(s):
(Dimethylamino)acetic acid
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About This Item
Linear Formula:
(CH3)2NCH2COOH
CAS Number:
Molecular Weight:
103.12
Beilstein:
1700261
EC Number:
MDL number:
UNSPSC Code:
41116105
PubChem Substance ID:
NACRES:
NA.22
grade
derivatization grade ((HPLC))
Quality Level
Assay
≥99% (NT)
quality
LiChropur™
technique(s)
HPLC: suitable
mp
178-182 °C (lit.)
suitability
suitable for LC-MS
SMILES string
CN(C)CC(O)=O
InChI
1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
InChI key
FFDGPVCHZBVARC-UHFFFAOYSA-N
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General description
N,N-Dimethylglycine is a type of quaternary ammonium compound which exhibits a variety of biological effects.
Application
N,N-Dimethylglycine has been used as a reference standard for the quantification of N,N-dimethylglycine in human plasma and serum by normal phase high performance liquid chromatography combined with triple-quadrupole tandem mass spectrometer (HPLC-MS/MS) operating on positive-ion mode, in human urine by stable-isotope dilution ultra-performance liquid chromatography−tandem mass spectrometry (UPLC−MS/MS) as well as UPLC coupled with quadrupole linear ion trap MS and in various soy sauces as hydrophilic metabolites by HPLC-MS.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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A method for comprehensive analysis of urinary acylglycines by using ultra-performance liquid chromatography quadrupole linear ion trap mass spectrometry.
Lewis-Stanislaus AE and Li L
Journal of the American Society For Mass Spectrometry, 21(12), 2105-2116 (2010)
Comprehensive analytical method for the determination of hydrophilic metabolites by high-performance liquid chromatography and mass spectrometry.
Yoshida H, et al.
Journal of Agricultural and Food Chemistry, 55(3), 551-560 (2007)
Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry.
Kirsch SH, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 878(32), 3338-3344 (2010)
Xuntian Jiang et al.
Journal of lipid research, 52(7), 1435-1445 (2011-04-27)
Niemann-Pick type C1 (NPC1) disease is a rare, progressively fatal neurodegenerative disease for which there are no FDA-approved therapies. A major barrier to developing new therapies for this disorder has been the lack of a sensitive and noninvasive diagnostic test.
T Santa
Drug discoveries & therapeutics, 7(1), 9-17 (2013-03-26)
Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) has been frequently utilized for the sensitive and selective determination of the trace level compounds in biological samples. In LC/ESI-MS/MS, chemical derivatization is sometimes used to enhance the detection sensitivity
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