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Merck
CN

06952

Benzocaine

tested according to Ph. Eur.

Synonym(s):

Benzocainum, 4-Aminobenzoic acid ethyl ester, Ethyl 4-aminobenzoate

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About This Item

Empirical Formula (Hill Notation):
C9H11NO2
CAS Number:
94-09-7
Molecular Weight:
165.19
EC Number:
202-303-5
UNSPSC Code:
12352200
PubChem Substance ID:
329748311
Beilstein/REAXYS Number:
638434
MDL number:
MFCD00007892

Key Documents

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Quality Level

100

agency

USP/NF, tested according to Ph. Eur.

form

crystalline

solubility

alcohol: soluble 1 gm in 5 ml, chloroform: soluble 1 gm in 2 ml, diethyl ether: soluble 1 gm in 4ml, olive oil: soluble 1 gm in 30-50 ml, water: soluble 1 gm in 2500 ml

application(s)

pharmaceutical (small molecule)

SMILES string

CCOC(=O)c1ccc(N)cc1

InChI

1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3

InChI key

BLFLLBZGZJTVJG-UHFFFAOYSA-N

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Application

Benzocaine has been used as animal anesthetic.

Biochem/physiol Actions

Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the nerve membrane, stopping the propagation of the action potential.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

233.6 °F

flash_point_c

112 °C

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBV1168
BCBT5299
BCBS5889V

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Renin, atrial natriuretic peptide and blood plasma ions in parr and smolts of atlantic salmon salmo salar l. and rainbow trout oncorhynchus mykiss (walbaum) in fresh water and after short-term exposure to sea water.
N. F. Smith
The Journal of Experimental Biology, 63-74 (1991)
Tyrone B Hayes et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(8), 5476-5480 (2002-04-18)
Atrazine is the most commonly used herbicide in the U.S. and probably the world. It can be present at several parts per million in agricultural runoff and can reach 40 parts per billion (ppb) in precipitation. We examined the effects
Nathalie Ferreira Silva De Melo et al.
Journal of pharmaceutical sciences, 101(3), 1157-1165 (2011-11-23)
This paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(D,L-lactide-co-glycolide), poly(L-lactide) (PLA), and poly(ε-caprolactone) and used as carrier systems for the local anesthetic (LA) benzocaine (BZC). The systems were characterized and their anesthetic activities investigated.
Sherry I Bame et al.
American journal of preventive medicine, 43(6 Suppl 5), S435-S442 (2012-11-28)
Hurricanes Katrina and Rita struck the Gulf Coast forcing unprecedented mass evacuation and devastation. Texas 2-1-1 is a disaster communication hub between callers with unmet needs and community services at disaster sites and evacuation destinations. To describe the location and
Qing Zhu et al.
Molecular pharmaceutics, 9(3), 546-553 (2012-02-04)
The crystallization kinetics of various active pharmaceutical ingredient/polyethylene glycol (API/PEG) solid dispersions has been investigated using wide-angle X-ray diffraction (XRD) and Raman spectroscopy. APIs with different physicochemical properties and crystallization tendency were employed to form solid dispersions with PEG. The
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Global Trade Item Number

SKUGTIN
224944-50G04061838779359
224944-10G04061838779342

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