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07297

Xylometazoline hydrochloride

analytical standard

Synonym(s):

2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2 · HCl
CAS Number:
1218-35-5
Molecular Weight:
280.84
NACRES:
NA.24
PubChem Substance ID:
329748399
UNSPSC Code:
41116107
EC Number:
214-936-4
MDL number:
MFCD00238707
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grade

analytical standard

Quality Level

100

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤1.0% water

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

CC1=CC(C(C)(C)C)=CC(C)=C1CC2=NCCN2.Cl

InChI

1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

InChI key

YGWFCQYETHJKNX-UHFFFAOYSA-N

General description

Xylometazoline hydrochloride is a derivative of imidazole, and a representative of the class of α1 agonists. It is commonly used in nasal decongestants, which works on the principle of constricting the blood vessels in the mucous membranes.

Application

Xylometazoline hydrochloride may be used as a reference standard in determining the xylometazoline hydrochloride content in samples of nasal drops using high performance liquid chromatography (HPLC).

Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline binding site ligand.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK3708
BCCD1262
BCBX5861
BCBV4755
BCBQ7274V

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High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate.
Milojevic Z, et al.
Journal of Chromatography A, 949(1-2), 79-82 (2002)
Pharmaceutical Chemistry E-Book (2011)
Decongestant activity of a new formulation of xylometazoline nasal spray: a double-blind, randomized versus placebo and reference drugs controlled, dose-effect study.
FC and GM
Drugs Under Experimental and Clinical Research, 28(1), 27-35 (2002)