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Merck
CN

10792

Antimycin A from Streptomyces sp.

mixture of the components A1, A2, A3 and A4, ~90% (HPLC)

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About This Item

CAS Number:
UNSPSC Code:
12352200
MDL number:
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assay

~90% (HPLC)

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O

InChI

1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1

InChI key

UIFFUZWRFRDZJC-RBVQMQRASA-N

General description

Chemical structure: peptide

Biochem/physiol Actions

Inhibitor of electron transfer at complex III. Induces apoptosis.

Other Notes

Inhibits the electron transport system

pictograms

Skull and crossbonesEnvironment

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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G. Hind et al.
Proc. Int. Congr. Photosynth., 4th, D.O. Hall et al., eds., 591-591 (1977)
D Pietrobon et al.
European journal of biochemistry, 117(2), 389-394 (1981-07-01)
The effect of antimycin A and funiculosin, two inhibitors which block electron transfer in the b-c1 complex, on electron flow and electrochemical potential difference of H+ ions in mitochondria at static head (state 4) is investigated. In addition, the respiratory
On the mechanism of inhibition of the respiratory chain by 2-heptyl-4-hydroxyquinoline-N-oxide.
G Izzo et al.
FEBS letters, 93(2), 320-322 (1978-09-15)
Rhianna Williams et al.
Developmental cell, 54(6), 758-772 (2020-08-01)
The loss of protein homeostasis (proteostasis) is a primary driver of age-related tissue dysfunction. Recent studies have revealed that the failure of proteostasis with age is triggered by developmental and reproductive cues that repress the activity of proteostasis-related pathways in
Stephanie A Zlatic et al.
Cell systems, 6(3), 368-380 (2018-02-06)
Rare neurological diseases shed light onto universal neurobiological processes. However, molecular mechanisms connecting genetic defects to their disease phenotypes are elusive. Here, we obtain mechanistic information by comparing proteomes of cells from individuals with rare disorders with proteomes from their

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