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Merck
CN

11099

Arsenic(III) oxide

puriss. p.a., ACS reagent, 99.95-100.05% (RT)

Synonym(s):

Arsenic trioxide, Arsenous acid

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About This Item

Empirical Formula (Hill Notation):
As2O3
CAS Number:
1327-53-3
Molecular Weight:
197.84
UNSPSC Code:
12352300
PubChem Substance ID:
57646847
EC Number:
215-481-4
MDL number:
MFCD00003433

Key Documents

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InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

InChI

1S/As2O3/c3-1-5-2-4

SMILES string

O=[As]O[As]=O

grade

ACS reagent, puriss. p.a.

vapor pressure

0.000001 mmHg ( 66 °C)

assay

99.95-100.05% (RT)

form

powder

anion traces

chloride (Cl-): ≤0.005%, sulfide (S2-): Pass

cation traces

Fe: ≤5 ppm, Pb: ≤0.002%, Sb: ≤0.05%

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Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

target_organs

Respiratory system,Cardio-vascular system,Gastrointestinal tract

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBD0655V
SLBC9730V
SLBB6616V
SLBB0811V
BCBC3502V

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Xinquan Li et al.
Cancer investigation, 22(3), 389-400 (2004-10-21)
Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast
Z X Shen et al.
Blood, 89(9), 3354-3360 (1997-05-01)
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15 APL patients at relapse after all-trans retinoic acid (ATRA) induced and chemotherapy maintained complete remission (CR). As2O3 was administered intravenously at
Cui Li et al.
Toxicology letters, 219(3), 223-230 (2013-04-02)
Arsenic trioxide (As2O3; ATO) is clinically effective in treating acute promyelocytic leukemia (APL); however, it frequently causes cardiotoxic effects. This study was designed to investigate whether ATO could induce apoptosis of cardiac fibroblasts (CFs) that play very important roles in
Ling-Huei Yih et al.
Toxicology and applied pharmacology, 267(3), 228-237 (2013-01-29)
Accumulated evidence has revealed a tight link between arsenic trioxide (ATO)-induced apoptosis and mitotic arrest in cancer cells. AKT, a serine/threonine kinase frequently over-activated in diverse tumors, plays critical roles in stimulating cell cycle progression, abrogating cell cycle checkpoints, suppressing
Huihui Wang et al.
Environmental toxicology, 28(5), 267-275 (2013-04-17)
Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. In this manuscript, we investigated 23 APL
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