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Merck
CN

11300

Asp-Phe methyl ester

≥99.0% (HPLC)

Synonym(s):

N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame

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About This Item

Linear Formula:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
CAS Number:
Molecular Weight:
294.30
EC Number:
245-261-3
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2223850
MDL number:
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assay

≥99.0% (HPLC)

impurities

≤4.5% water

mp

242-248 °C

storage temp.

2-8°C

SMILES string

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O

InChI

1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1

InChI key

IAOZJIPTCAWIRG-QWRGUYRKSA-N

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Jean-Daniel Berset et al.
Chemosphere, 88(5), 563-569 (2012-04-17)
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of
Eva S Schernhammer et al.
The American journal of clinical nutrition, 96(6), 1419-1428 (2012-10-26)
Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. We repeatedly assessed diet in the Nurses' Health Study (NHS) and
Maria Maersk et al.
The American journal of clinical nutrition, 95(2), 283-289 (2011-12-30)
The consumption of sucrose-sweetened soft drinks (SSSDs) has been associated with obesity, the metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies. Too few long-term intervention studies in humans have examined the effects of soft drinks. We compared
T J Maher et al.
Environmental health perspectives, 75, 53-57 (1987-11-01)
The artificial sweetener aspartame (L-aspartyl-L-phenylalanyl-methyl ester), is consumed, primarily in beverages, by a very large number of Americans, causing significant elevations in plasma and, probably, brain phenylalanine levels. Anecdotal reports suggest that some people suffer neurologic or behavioral reactions in
L D Stegink
The American journal of clinical nutrition, 46(1 Suppl), 204-215 (1987-07-01)
Toxicology is based on the premise that all compounds are toxic at some dose. Thus, it is not surprising that very large doses of aspartame (or its components--aspartate, phenylalanine, and methanol) produce deleterious effects in sensitive animal species. The critical

Global Trade Item Number

SKUGTIN
V800450-500G04061832752150
14439-1KG04061838735607
205532-100G04061838767783
1724747-200MG04061835346400
255750-100G04061826016916
721077-100G04061838254283
721085-100G04061832855998
108846902504022536108490
108849050004022536108520
108846902904022536946221
37-0480-5-500G-J04061832687698
677450-5G04061832748429
96479-1KG04061833318478
96479-500G04061833318850
V800450-5KG04061832752167
V800450-6X500G04061832752174
14439-100G04061838735591
14439-6X1KG04061833636305
204951-125G04061838767370

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