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Merck
CN

114189

Acetyl chloride

reagent grade, 98%, liquid

Synonym(s):

Acetic acid chloride, Acetic chloride, Ethanoyl chloride

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About This Item

Linear Formula:
CH3COCl
CAS Number:
75-36-5
Molecular Weight:
78.50
Beilstein:
605303
EC Number:
200-865-6
MDL number:
MFCD00000719
UNSPSC Code:
12352100
eCl@ss:
39050501
PubChem Substance ID:
24847160
NACRES:
NA.21

Key Documents

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Product Name

Acetyl chloride, reagent grade, 98%

grade

reagent grade

Quality Level

200

vapor density

2.7 (vs air)

vapor pressure

11.69 psi ( 20 °C)
32.33 psi ( 55 °C)

Assay

98%

form

liquid

autoignition temp.

1353 °F

expl. lim.

19 %

refractive index

n20/D 1.389 (lit.)

bp

52 °C (lit.)

mp

−112 °C (lit.)

density

1.104 g/mL at 25 °C (lit.)

functional group

acyl chloride

SMILES string

CC(Cl)=O

InChI

1S/C2H3ClO/c1-2(3)4/h1H3

InChI key

WETWJCDKMRHUPV-UHFFFAOYSA-N

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General description

Acetyl chloride is used as an acylating reagent for electrophilic acetylation of alkynes, alkenes, arenes, saturated alkanes, enolates, and organometallics.

Acetyl chloride is a colorless acyl halide. On reaction with ammonia and alcohols, it affords acetamide and esters of acetic acid, respectively. Structural parameters and rotational constants of its isotopic forms have been evaluated from the microwave spectral investigations.

Application

Acetyl chloride has been used in the Lepage and Roy fatty acids analysis, and robotic fatty acid analysis. It may be used for the qualitative in situ synthesis of hydrogen chloride.

Pictograms

FlameCorrosion
GHS02,GHS05

Signal Word

Danger

Hazard Statements

H225,H314

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Supplementary Hazards

EUH014

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

41.0 °F - closed cup

Flash Point(C)

5 °C - closed cup

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SDBB5700
STKB6762
SDBB0881
STBL4167
STBL4166

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Acetyl Chloride
Pearlman BA
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Acetyl Chloride-Methanol as a Convenient Reagent for: A) Quantitative Formation of Amine Hydrochlorides B) Carboxylate Ester Formation C) Mild Removal of Nt-Boc-Protective Group.
Nudelman A, et al.
Synthetic Communications, 28(3), 471-474 (1998)
Yu Hong Lin et al.
Lipids, 47(5), 527-539 (2012-03-21)
Large population studies show that polyunsaturated fatty acids are important for human health, but determining relationships between the health benefits and the fatty acid content has been hampered by the unavailability of labor-effective high-throughput technologies. An automated high throughput fatty
Microwave spectrum of acetyl chloride.
Sinnott, KM.
J. Chem. Phys. , 34(3), 851-861 (1961)
Eagleson M.
Concise Encyclopedia Chemistry, 4-4 (1994)
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