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12019

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine, 7-nitrobenzofurazan-labeled

Name: 1,2-Dipalmitoyl-<I>sn</I>-glycero-3-phosphoethanolamine, 7-nitrobenzofurazan-labeled
Brand: SIAL

ammonium salt, ≥98.0% (TLC)

Synonym(s):

2(R),3-dipalmitoylglycero-1 -phospho-N-(7-nitro-2,1,3-benzoxadiazo1-4-y1)ethanolamine, L-β,γ-Dipalmitoyl-α-cephaline, 7-nitrobenzofurazan-labeled, N-(7-Nitro-benzofurazan-4-yl)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, N-(7-Nitrobenzofurazan-4-yl)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, N-NBD-Dipalmitoyl-L-α-Phosphatidylethanolamine, NBD-PE, Phosphatidylethanolamine 16:0, NBD-labeled

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About This Item

Empirical Formula (Hill Notation):

C₄₃H₇₅N₄O₁₁P

CAS Number:

92605-64-6

Molecular Weight:

855.05

UNSPSC Code:

12352200

PubChem Substance ID:

329749595

MDL number:

MFCD06798167

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assay

≥98.0% (TLC)

fluorescence

λ_ex 459 nm; λ_em 528 nm in methanol

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

O=C(CCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC1=CC=C([N+]([O-])=O)C2=NON=C12)(O)=O

InChI

1S/C43H75N4O11P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-40(48)54-35-37(57-41(49)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-56-59(52,53)55-34-33-44-38-31-32-39(47(50)51)43-42(38)45-58-46-43/h31-32,37,44H,3-30,33-36H2,1-2H3,(H,52,53)/t37-/m1/s1

InChI key

ODWMPKRLTCWGFP-DIPNUNPCSA-N

Application

Phosphatidylethanolamine 16:0 can be utilized as a lipid fluorescent probe to study the morphological stability of lipid membranes (to surfactants and ethanol) by monitoring its fluorescence.

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Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Shen Wang et al.

Nature communications, 10(1), 69-69 (2019-01-10)

The transition of the Munc18-1/syntaxin-1 complex to the SNARE complex, a key step involved in exocytosis, is regulated by Munc13-1, SNAP-25 and synaptobrevin-2, but the underlying mechanism remains elusive. Here, we identify an interaction between Munc13-1 and the membrane-proximal linker

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