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Merck
CN

125660

Leucomalachite Green

powder

Synonym(s):

4,4′-Benzylidenebis(N,N-dimethylaniline)

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About This Item

Linear Formula:
C6H5CH[C6H4N(CH3)2]2
CAS Number:
Molecular Weight:
330.47
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
204-961-9
Beilstein/REAXYS Number:
2140506
MDL number:
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Product Name

Leucomalachite Green, powder

InChI key

WZKXBGJNNCGHIC-UHFFFAOYSA-N

InChI

1S/C23H26N2/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4/h5-17,23H,1-4H3

SMILES string

CN(C)c1ccc(cc1)C(c2ccccc2)c3ccc(cc3)N(C)C

form

powder

technique(s)

microbe id | staining: suitable

mp

100-102 °C (lit.)

λmax

623 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

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Application

Leucomalachite green has been used as a reagent in presumptive tests which are used to detect invisible blood stains.

Biochem/physiol Actions

Leucomalachite green (LMG) is a chief metabolite of malachite green, a triphenylmethane dye that has been used generally as an antifungal drug in the fish industry. DNA adducts formed in livers of rats fed with leucomalachite green have been observed with little mutagenic or carcinogenic effect. LMG is one of the most commonly used reagents for presumptive blood test. It gives a characteristic green color in the presence of blood. LMG destroys DNA in the blood, therefore, the chances of DNA recovery and amplification is reduced or eliminated.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Muta. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Becker, Ronald F. Becker, Aric W. Dutelle
Criminal Investigation (2012)
Evidence of aerosolised floating blood mist during oral surgery.
Ishihama K
Journal of Hospital Infection, 71(4), 359-364 (2009)
Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green.
Culp SJ
Mutation Research, 506-507, 55-63 (2002)
David Arroyo et al.
Journal of chromatography. A, 1216(29), 5472-5482 (2009-06-19)
This paper reports a multiresponse optimization of an extraction procedure in the simultaneous determination of malachite green (MG) and its metabolite (leucomalachite green, LMG) in fish by liquid chromatography with triple quadrupole mass spectrometry (LC-MS/MS). Prior to optimization, the active
Kamila Mitrowska et al.
Journal of chromatography. A, 1207(1-2), 94-100 (2008-09-06)
A liquid chromatography with visible and fluorescence detection (LC-vis/FLD) method for screening and a liquid chromatography with mass spectrometry (LC-MS/MS) method for the confirmation of malachite green (MG) and its major metabolite, leucomalachite green (LMG) residues in water have been

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