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Merck
CN

14405

(+)-Biotin N-hydroxysuccinimide ester

≥95% (HPLC)

Synonym(s):

(+)-Biotin N-succinimidyl ester, d-Biotin NHS ester, BNHS, Biotinyl-N-hydroxy-succinimide, N-Hydroxysuccinimidobiotin, N-Succinimidyl D-biotinate, NHS-Biotin

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About This Item

Empirical Formula (Hill Notation):
C14H19N3O5S
CAS Number:
35013-72-0
Molecular Weight:
341.38
PubChem Substance ID:
329750289
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
4720781
MDL number:
MFCD00078531

Key Documents

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SMILES string

[H][C@]12CS[C@@H](CCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2

InChI

1S/C14H19N3O5S/c18-10-5-6-11(19)17(10)22-12(20)4-2-1-3-9-13-8(7-23-9)15-14(21)16-13/h8-9,13H,1-7H2,(H2,15,16,21)/t8-,9-,13-/m0/s1

InChI key

YMXHPSHLTSZXKH-RVBZMBCESA-N

biological source

synthetic

assay

≥95% (HPLC)

form

powder

optical activity

[α]20/D +53±1°, c = 1% in DMF

color

white to off-white

mp

212-214 °C

storage temp.

−20°C

Quality Level

500

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Other Notes

Activated biotin, generally used for attaching biotin to amino acids, peptides and proteins; Review: The use of the avidin-biotin complex as a tool in molecular biology; On-resin biotinylation of chemically synthesized proteins for one-step purification

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Maria Livia Bernardi et al.
PloS one, 6(11), e27856-e27856 (2011-11-25)
Food allergy is increasingly common worldwide. Tools for allergy diagnosis measuring IgE improved much since allergenic molecules and microarrays started to be used. IgE response toward allergens belonging to the same group of molecules has not been comprehensively explored using
Tue W Kragstrup et al.
Arthritis research & therapy, 16(1), R42-R42 (2014-02-05)
Spondyloarthritis (SpA) comprises a group of diseases often associated with HLA-B27 and characterized by inflammation of the entheses and joints of the axial skeleton. The inflammatory process in SpA is presumably driven by innate immune cells but is still poorly
T J Lobl et al.
Analytical biochemistry, 170(2), 502-511 (1988-05-01)
A general, convenient, one-step purification procedure for chemically synthesized proteins present in low yields using on-resin biotinylation is reported. The protein, terminally deprotected and neutralized on-resin, is stirred in dimethylformamide and then biotinylated with N-hydroxysuccinimidobiotin (2 mg/mg protein on-resin) for
K. Hoffmann et al.
Journal of the American Chemical Society, 100, 3585-3585 (1978)
Xiao-Lin Luo et al.
Cancer research, 78(13), 3532-3543 (2018-05-08)
A high rate of disease relapse makes epithelial ovarian cancer (EOC) the leading cause of death among all gynecologic malignancies. These relapses are often due to tumor dormancy. Here we identify the RNA polymerase II transcriptional mediator subunit 12 (MED12)
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