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Merck
CN

16082

2-Bromoacetamide

purum, ≥98.0% (GC)

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About This Item

Linear Formula:
BrCH2CONH2
CAS Number:
Molecular Weight:
137.96
PubChem Substance ID:
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
1739073
MDL number:
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grade

purum

assay

≥98.0% (GC)

mp

87-91 °C

SMILES string

NC(=O)CBr

InChI

1S/C2H4BrNO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

JUIKUQOUMZUFQT-UHFFFAOYSA-N

General description

Kinetics of reaction of 2-bromoacetamide with a 39 base pair duplex DNA sequence was studied.

Application

2-Bromoacetamide was used in the preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester.

pictograms

Skull and crossbonesCorrosion

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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M J Taylor et al.
Bioconjugate chemistry, 8(3), 354-364 (1997-05-01)
Attachment of a nondiffusible bromoacetyl electrophile to the 5-position of a thymine at the 5'-end of a pyrimidine oligodeoxyribonucleotide affords sequence-specific alkylation of a guanine base in duplex DNA two base pairs to the 5'-side of a local triple-helical complex.
Susanna Tchilibon et al.
Journal of medicinal chemistry, 48(6), 1745-1758 (2005-03-18)
A series of ring-constrained (N)-methanocarba-5'-uronamide 2,N(6)-disubstituted adenine nucleosides have been synthesized via Mitsunobu condensation of the nucleobase precursor with a pseudosugar ring containing a 5'-ester functionality. Following appropriate functionalization of the adenine ring, the ester group was converted to the
George R Kracke et al.
ChemMedChem, 10(1), 62-67 (2014-11-26)
Clinically there is a need for local anesthetics with a greater specificity of action on target cells and longer duration. We have synthesized a series of local anesthetic derivatives we call boronicaines in which the aromatic phenyl ring of lidocaine

Global Trade Item Number

SKUGTIN
217883-50G04061833595619
217883-10G04061838775177

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