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Merck
CN

17081

Fura-2 LeakRes (AM)

≥95% (TLC)

Synonym(s):

Fura PE 3-AM

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About This Item

Empirical Formula (Hill Notation):
C55H63N5O29
CAS Number:
172890-84-5
Molecular Weight:
1258.10
UNSPSC Code:
12171500
PubChem Substance ID:
329751473
MDL number:
MFCD00285848

Key Documents

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InChI

1S/C55H63N5O29/c1-33(61)76-27-82-49(68)22-57-11-13-58(14-12-57)48(67)10-8-39-7-9-41(59(23-50(69)83-28-77-34(2)62)24-51(70)84-29-78-35(3)63)44(17-39)74-15-16-75-45-18-40-19-46(54-56-21-47(89-54)55(73)87-32-81-38(6)66)88-43(40)20-42(45)60(25-52(71)85-30-79-36(4)64)26-53(72)86-31-80-37(5)65/h7,9,17-21H,8,10-16,22-32H2,1-6H3

SMILES string

CC(=O)OCOC(=O)CN1CCN(CC1)C(=O)CCc2ccc(N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OCCOc3cc4cc(oc4cc3N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c5ncc(o5)C(=O)OCOC(C)=O)c2

InChI key

CGAZNAYDEAJZHQ-UHFFFAOYSA-N

assay

≥95% (TLC)

solubility

DMSO: soluble

fluorescence

λex 335 nm; λem 495 nm in 0.1 M Tris pH 8.0, esterase; 10 mM Ca2+

suitability

suitable for fluorescence

storage temp.

−20°C

Application

Fura 2 is one of the most widely used calcium indicators for ratiometric measurement and is highly suitable for digital imaging microscopy.

Features and Benefits

Pale yellow gum. Cell permeable acetoxymethyl ester (AM) derivative of Fura-PE3 with spectral properties similar to the parent compound.

Other Notes

Cell permeable ester of fluorescent calcium probe; abs.: λmax 364 nm; em.: λmax 502 nm

Regulatory Information

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F Abe et al.
British journal of pharmacology, 116(7), 3000-3004 (1995-12-01)
1. To examine whether cytosolic Ca2+ in smooth muscle cells distributes evenly, cytosolic Ca2+ levels were measured with two different Ca2+ indicators in the ferret isolated portal vein; a fluorescent indicator, fura-PE3, that shows the average Ca2+ level, and a
E P Milner et al.
The Journal of laboratory and clinical medicine, 131(1), 49-62 (1998-02-06)
High shear stress in narrowed arteries causes von Willebrand factor (vWf) to bind to its platelet receptor, glycoprotein Ib (GpIb). This binding is reported to promote an increase in intracellular free calcium concentration ((Ca2+)i), which may be responsible for platelet
Entaz Bahar et al.
International journal of molecular sciences, 21(20) (2020-10-21)
 Ovarian cancer (OC) is the most lethal of the gynecologic cancers, and platinum-based treatment is a part of the standard first-line chemotherapy regimen. However, rapid development of acquired cisplatin resistance remains the main cause of treatment failure, and the underlying
Nara Shin et al.
Polymers, 12(5) (2020-05-06)
p66shc, a member of the shc adaptor protein family, has been shown to participate in regulation of mitochondrial homeostasis, apoptosis, and autophagosome formation. The present study was performed to investigate whether p66shc siRNA-encapsulated poly(d,l-lactic-co-glycolic acid) nanoparticles (p66shc siRNA-PLGA NPs) can

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