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Merck
CN

17281

Supelco

1-(Pentafluoropropionyl)imidazole

derivatization grade (GC derivatization), ≥98.5%

Synonym(s):

PFPI, 1-(Perfluoropropionyl)imidazole

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About This Item

Empirical Formula (Hill Notation):
C6H3F5N2O
CAS Number:
71735-32-5
Molecular Weight:
214.09
EC Number:
275-944-1
MDL number:
MFCD00014502
UNSPSC Code:
41116105
PubChem Substance ID:
329751298
NACRES:
NA.22

Key Documents

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grade

derivatization grade (GC derivatization)

Quality Level

100

Assay

≥98.5% (GC)
≥98.5%

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

GC/MS: suitable

refractive index

n20/D 1.399

density

1.4 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

FC(F)(F)C(F)(F)C(=O)n1ccnc1

InChI

1S/C6H3F5N2O/c7-5(8,6(9,10)11)4(14)13-2-1-12-3-13/h1-3H

InChI key

VZUSRIIEPFQBNE-UHFFFAOYSA-N

General description

Derivatization before a GC analysis helps in yielding distinctive products, which can be achieved using a derivatizing reagent that reacts with amino and hydroxyl functionalities quantitatively. 1-(Pentafluoropropionyl)imidazole (PFPI) is a derivatizing reagent which was found to give high yield of products than pentafluoropropionic anhydride during preparation of methyl ester/pentafluoropropionyl derivatives.

Application

PFPI may be used to incubate the lyophilized samples, for derivatization during GC/MS analysis to measure total d-chiro-Inositol content absorbed by rodents.

Other Notes

Derivatization agent for alcohols and carboxylic acids, etc. in GC
Reagent for methyl ester, pentafluoropropionyl.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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F Karoum et al.
British journal of pharmacology, 56(4), 403-411 (1976-04-01)
1 Mass fragmentography was used to measure whole brain concentrations of some of the major metabolites of tyramine, octopamine, dopamine and noradrenaline in acutely treated and in ethanol-dependent rats. 2 Treatments with ethanol, either acutely or chronically, failed to alter
F. Karoum et al.
Biomedical Mass Spectrometry, 2, 183-183 (1975)
J.T. Etse et al.
Journal of Natural Products, 51, 314-314 (1988)
Xiaobo Lin et al.
The British journal of nutrition, 102(10), 1426-1434 (2009-07-10)
d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. DCI-containing compounds are abundant in common laboratory animal feed. By GC-MS of 6 m-HCl hydrolysates, Purina Laboratory Rodent Diet 5001 (diet 5001) contained 0.23 % total DCI
D.R. Knapp
Handbook of Analytical Derivatization Reactions, 208-208 (1979)
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